The Biochemical Beauty of Retatrutide: How GLP-1s Work

mchusma•about 1 hour ago

Retatrutide is incredible in a mind altering way. I know 4 people on it, including myself. And all just love the way it makes you feel. You just don’t want to eat as much and you want to eat healthier. As far as I can tell, that is it. While I’m nervous there could be long term side effects, I think the health benefits of being at a healthy weight mean that for probably 50% of the developed world they would benefit from it.

Looking forward to more formal studies though!

jfreds•1 minute ago

I tried semaglutide and while it was effective for losing weight, it made working out impossible (felt exhausted and very sick as soon as hr went up) and it made hangovers awful. Is retatrutide any different?

nose•42 minutes ago

How is everyone purchasing Retatrutide at this moment? It's still in phase 3 trials, and I keep hearing of people being on it. Not really seeing safe options with proper lab testing.

Other pharmaceuticals at the phase 3 stage (such as Buntanetap for Parkinson's disease) are super difficult to get, even with the right to try exemption in the US.

elteto•1 minute ago

Wellness/Health clinics sourcing from China or compounding pharmacies, which themselves source the ingredients from China.

antinomicus•36 minutes ago

Yeah, I hear everyone talk about it like it’s just super easy to get…

bsamuels•20 minutes ago

they buy it from research peptide vendors

icameron•about 1 hour ago

Does it alter you mind more than just your appetite for healthy food like you said? Is there a buzz or general mood lift as well?

cj•about 1 hour ago

If there's any mental effect, it's most likely from eating less food (and most likely healthier food) and feeling better because of that.

It doesn't increase your appetite for healthy food. It will punish you for eating bad food. "Don't eat that steak, you're going to have crazy stomach pain tomorrow if you do!"

stavros•11 minutes ago

That's not my experience with tirzepatide. When it worked for me (which was a brief period, admittedly), it kind of turned me off fatty foods, and I wouldn't want to have pizza, for example, but I'd crave a chicken breast and boiled potato, or salad.

When it didn't work, one of the failure modes was that I still craved fatty/fried food, but I got terrible stomach pain from it, which is the worst of both worlds. If I'm still going to be unable to resist food, I don't want to be punished for it any more than I already am by being overweight!

stavros•about 1 hour ago

Unfortunately, my experience with tirzepatide doesn't make me hopeful: It either gave me terrible diarrhea and sulfur burps, or it did nothing at all, even on 15mg. Hopefully retatrutide is different, but I'm not holding my breath.

It did work for around two weeks, though, and it was great. I constantly felt mildly carsick, so I didn't really want to eat anything, but also didn't have much trouble eating my macros.

zemvpferreira•38 minutes ago

Sorry to hear that. As a counterpoint for the peanut gallery I've been on tirzepatide for 5 months and lost 15 kg in the first 3 months, never going past a 1.25mg dose. I've only creeped up to 3mg since and keep losing around 0.3 kg per week. No side effects except for super mild nausea every now and then. I plan to stay at a similar or lower dose for the next couple of years.

I had the good fortune of responding well and being at a great starting point: despite being 40% body fat I exercised a lot and had great labs to begin with. Anecdotally I've found starting metabolic health to make a huge difference in dose response.

stavros•33 minutes ago

Thanks, everyone else I know who's tried it has had great results, I guess I'm just unlucky :/

cj•about 1 hour ago

How did you get to 15mg and only had it working for 2 weeks? The starting dose is 2.5mg and it takes many months to titrate up to 15mg. Most people never get to 15mg.

I've read hundreds of anecdotal experiences from people on these drugs, and haven't encountered anyone taking 15mg without success.

stavros•about 1 hour ago

> How did you get to 15mg and only had it working for 2 weeks?

Shrug, it's a mystery to me as well. It did take many months to get to that point.

gedy•37 minutes ago

Everyone is different but I lost over 40lbs just by taking 5mg over about 5 months

zoba•about 1 hour ago

I hope it is more effective that Tirzepatide of which I am a rare nonresponder and have only gained weight.

The Biochemical Beauty of Retatrutide: How GLP-1s Work

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