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Analyzed from 1855 words in the discussion.

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#cats#humans#more#cat#years#don#better#temperature#pill#food

Discussion (60 Comments)Read Original on HackerNews

busssard•42 minutes ago
We will see more and more fungi infecting mammals in the coming years. Mammals and birds evolved higher body temperatures in part to protect from fungal infections. As most fungi are dying above 37°C. But a high temperature summer is a selection pressure on any mushroom trying to survive, and hence might evolve to survive 40° summers and thus also survive in our bodies.

I really hope cordyceps is one of the last to do this step.

trevithick•6 minutes ago
The article doesn't address treatment efficacy in humans. How is it treated? How effective is the treatment? Can this develop resistance to the treatment? The spread mechanisms and persistence are concerning, but without info on treatment I'm not sure how much I should freak out about this.
MisterTea•about 1 hour ago
> “I’m convinced that half of the human cases that come from cats are people who are trying to stuff pills down their cat’s throats to treat the sporotrichosis,”

Do yourself a favor, crush the pill and put it in food. Problem solved. Difficult with multiple cats but I had two and one needed medication so I put this little guys on a window sill he loved to perch on which the other cat didn't care to reach.

drdexebtjl•36 minutes ago
This doesn’t necessarily work. Some pills taste bad, and the cat will refuse weird-tasting food.

I recommend everyone who has healthy cats to talk to their vet about administering empty capsules. Just so you and the cat get comfortable with the process before you need it.

Kind of like you need to train them from an early age that clipping their nails is fine.

When your cat gets old, they will need to take oral supplements, at the very least. You’re the person they trust the most to give them.

jsiepkes•41 minutes ago
Its not always that easy. For example cerenia tastes very bitter for a cat. My cat will start drooling almost uncontrollably if he tastes it. He has a kidney condition and needs it for the rest of his life. I've tried crushing it, but he will then just ignore the food because of the bitter taste of the pill. Putting it in something like easy-pill will work a couple of times. Until he realizes the disgusting taste he is going to experience when eating the easy-pill. At that point you can't trick him anymore with an easy-pill.

So the only way I can give it to him (without drama) is by putting it deep into his mouth so he never tastes it and immediately swallows it.

pikminguy•about 1 hour ago
A. I have cats that don't go anywhere special that the other cats don't go so that doesn't work unless I supervise. B. It's difficult to make sure they get the entire dose, again unless you supervise. And good luck getting a cat to finish food they've decided they are done with. C. I have cats that are picky enough to ignore any food that has a crushed pill in it. They can always tell. Yes even if I use smelly food. D. Not all medications can be safely crushed. Slowly dissolving in the stomach could be an important aspect of the delivery.
Chazprime•about 1 hour ago
Can survive weeks, months and even years??

That’s a little horrifying.

gchamonlive•15 minutes ago
My cat's got a different kind of fungus, not sporotrichosis, but one that gives her sort of a "clown nose". We've been trying to treat it for years now and it always comes back. Every time the treatment takes 4-6 months with itraconazol.
simonebrunozzi•about 1 hour ago
Reminds me of the TV Series "The Last of us" [0], which: "... is set decades after the collapse of society caused by a mass fungal infection that transforms its hosts into zombie-like creatures". Of course, minus the zombies.

[0]: https://en.wikipedia.org/wiki/The_Last_of_Us_(TV_series)

userulluipeste•39 minutes ago
We are lucky that mass epidemics that plagued humans so far didn't affect the brain. Affections like rabies, that require individuals biting each other, and which are the inspirational source of all those zombie fantasies, do not count. That is an attack vector easy to spot and manage. The scary scenario is the one like with this Sporothrix Brasiliensis fungus, which can spread by merely "sneezing out the infectious yeast", and then remaining potent (outside a host) for "up to 10 weeks", plus (the cherry on top) -- "developing the disease three years after" the infection event. Any kind of pandemic is scary by the sheer magnitude of its reach, but one that would affect the brain? That would be another level of scary.
dguest•38 minutes ago
In the opening scene a scientist argues once the ambient temperature of some region is 37°C we'll all get eaten by fungus. It will evolve to live at body temperature.

There are some precedents for this: hibernating bats lower their body temperature to that of a moldy environment, and are getting infected with a fungus which kills 90% of them in some cases [2]. Logic goes that raising the ambient temperature could be the same (with some evolution thrown in) as lowering our body temperature.

Is it credible? No idea, not that kind of scientist.

[1]: https://www.youtube.com/watch?v=OLNagvJHl3g

[2]: https://en.wikipedia.org/wiki/White-nose_syndrome

phyzix5761•about 1 hour ago
You mean the video games?
recursive-call•about 1 hour ago
There is also a TV adaptation that came out on Netflix a few years ago.
Sharlin•about 1 hour ago
I guess GP is hinting that referring to TLoS as a TV series is a bit similar to, say, referring to LotR as a movie series (when discussing the basic premise shared by the original and the adaptation).
Ralfp•about 1 hour ago
It's HBO Original actually
feverzsj•about 1 hour ago
Deadly to immunocompromised people. Basically everything could be deadly to them. Cats also rarely attack human proactively. So not really a big concern.
kevlened•about 1 hour ago
It can be airborne, lives on sanitized surfaces for up to 10 weeks, and may take 3 years for symptoms to appear.

Still, it is more concerning for cats than humans.

greenavocado•43 minutes ago
Hypochlorous acid (HOCl) is highly effective at killing Sporothrix fungi, including Sporothrix brasiliensis

HOCl is the best non-toxic broad spectrum human compatible antimicrobial. I have been using it in many household applications since COVID started.

It can be prepared by electrolysis of acidified (e.g. vinegar, but ideally pH 5.5, and inorganic acids make it last way longer at that pH, but they are more dangerous to handle) salt water (high margin of safety) or alternatively prepared by mixing highly diluted bleach with an diluted acid (low margin of safety) to target 20-2000 ppm depending on your delivery method (e.g. one tablespoon of bleach and vinegar into a gallon of water). If you are worried about the safety of this approach, note that far, far less chlorine gas is emitted when made this way than by ordinary bathroom cleaning with a bleach-based bathroom cleaner.

The smell of HOCl is unique and completely different from chlorine gas. The small amount of chlorine gas emitted likes to sit on top of the surface of the water, but if this layer is blown away, the distinct smell of HOCl becomes apparent immediately. It smells like minty bubblegum or something more familiar: a swimming pool.

The good news is when making HOCl for disinfection purposes 20-2000 ppm, only very small quantities of chlorine gas are evolved. They can be reduced further by shaking the closed container used to make it, further dissolving the gas into solution to make more HOCl.

I run this solution in my humidifier at low concentrations to prevent microorganisms from growing in it. I also use the electrolysis method to accurately make very low concentrations for nasal rinses. Typically, 15-30 seconds from a $10 USB electrolyzer in salt water.

dosisking•about 1 hour ago
It's hard to take an article that uses the word 'ginormous' seriously
helsinkiandrew•about 1 hour ago
I think quoting is fine, but it's surprising coming from a senior adviser at a U.S. Government department.

> “What we have right now is this ginormous ongoing outbreak of Sporothrix brasiliensis in Brazil,” Lockhart, a senior adviser at the U.S. Centers for Disease Control and Prevention

LargeWu•about 1 hour ago
It's a perfectly cromulent word.
doodlebugging•32 minutes ago
I agree even though I use ginormous in normal conversation. In the right context it is fine, I just don't think this is the right context.

I also find it hard to take an article seriously when its volume comparison employs "Olympic-sized swimming pools". I think the fraction of people who have a clear enough mental idea of the dimensions or volume of an Olympic-sized swimming pool is pretty small relative to the articles readership, which I hope they measure realistically under the assumption that the number of readers will always be close to half the number of eyeballs on the page. Otherwise they would be inflating readership and that would be misleading.

alpinisme•about 1 hour ago
The article doesn’t. It quotes a CDC advisor who does.
abanana•about 1 hour ago
It probably does a better job of getting the point across to a general readership than if they'd used overly technical domain-specific jargon about quantity of cases and speed of its spread.
bandofthehawk•about 1 hour ago
Technical jargon like "gigantic" or "enormous"?
elzbardico•21 minutes ago
Please note that this is an extremely rare disease even in Brazil, where it came from. Asked my vet, and two cousins who also are vets, and all of them knew of the disease from scientific literature and government health bulletins, but only one of them had treated two actual cases, when he lived in northeastern region: two strays.

Brasil must have something like between 40 and 50 million cats (including strays). An infectious disease that killed thousands (what the article means? 1000, 2000? 10000?) while not ignorable, it is not exactly highly prevalent.

mghackerlady•17 minutes ago
>infect cats

No! We must stop this at all costs

>and people

Eh, all right then. If it takes the cats out at least we'd be going with them

everdrive•about 2 hours ago
Everything is spreading. We're a large interconnected world, and we'll inherit everyone's problems eventually. There are better alternatives, but it's not something people will seriously consider.
elzbardico•13 minutes ago
Do you live in the American continent? Look at the skin tone of most people you find in the streets. Go to a library and try to find out what was the average skin tone in your region 600 years ago. Compare both.

Thinks have been spreading for quite a while. Migratory species are older than ourselves. Jet stream can carry spores over oceans. World commerce is older than you think. Wars and migratory movements has always been a part of our civilization.

happytoexplain•about 1 hour ago
Don't be ominous. Just say things or refrain from posting.
andreime•about 2 hours ago
Please name a better alternative, I'm very curious.
symian•about 1 hour ago
A system that prices in cost of negative externalities is better than what we have now. A system that caps how much wealth a person can have is a better system that what we now have. A system that prevents the exportation of pollution is a better system than what we have now.

These are opinions and I understand not everyone has these same beliefs.

everdrive•about 1 hour ago
One where people don't travel very much.
mc32•about 2 hours ago
What are the alternatives people rather avoid considering?
rob74•about 1 hour ago
Not the OP, and this is probably not what they were thinking of, but from the point of view of the planet's ecosystem, eliminating the humans that keep introducing species where they don't belong (or at least drastically reducing their population) would be the most effective measure.
elzbardico•10 minutes ago
There's no such thing as introducing species where they don't belong. Ecosystem are dynamic, several other animals serve as vectors for transporting species from a place to another. There's no such thing as a long term static equilibria where godess gaia looks like a Jehova's witnesses book illustration. This is an incredibly cultish and misanthropic position.
hagbard_c•about 1 hour ago
You first?

Also, what is that babble about "the planet's ecosystem" being better off by eliminating humans? If you really want to see it as a whole - the Gaia hypothesis - then humans are part of it just like flies and ticks and mosquitos and birds and whales. All play a role, some spread diseases to others while they feed yet again others. Removing humans from the equation is just like Mao's decision to get rid of the sparrows which ate some of the harvest in that the balance will shift until a new equilibrium has been reached. In Mao's case it killed tens of millions of humans, removing humans will result in the death of hundreds of millions of other species.

rvba•about 1 hour ago
Probably something about walls or methods used by political systems that built walls.
shahsjsjjsz•about 2 hours ago
Not having cats is an option that is not seriously considered.

Dogs are even worse. Make them shit in your own backyard please.

If you are a city dweller please do not keep “pets”, it’s bloody ridiculous, thank you.

nemomarx•about 1 hour ago
We've been keeping pets as a species for considerably longer than we've had cities. It's basically an ingrained part of how we react to animals now.
wafflemaker•6 minutes ago
In dwarf fortress you can have dragons as pets. Never got there, tho I think I will train dogs in my current fortress.
lenerdenator•about 1 hour ago
Beyond that, longer than we've had the written word.

Domestication of animals might be the single greatest achievement of humans.

andrew_lettuce•about 1 hour ago
You seem to think humans keep cats as pets, which indicates you've never lived with a cat before.
swader999•about 1 hour ago
We need lock downs, a wall, 100% containment. Full vaccine mobilization. Starship must be expedited. A world without cats is not a world at all.
croes•about 1 hour ago
A world with cats is a world with billions of dead birds and small mammals.

Without them we will have even more insects.

So this time cats won’t protect us from diseases by killing the carrier, these time they help the carriers

throwaway173738•14 minutes ago
Or killing them in the US will allow bird populations to recover, leading to birds killing more insects. Cats are not native to the Americas.
mb_thd•27 minutes ago
They still kill carriers for other stuff. Pick your poison, I guess.
hsbauauvhabzb•about 1 hour ago
Wouldn’t we have less insects because of increased bird, rodent and spider growth?
zeristor•about 1 hour ago
Less insecticide is probably the key thing.

Driving in the eighties with windscreens full of insects, and now hardly anything, and a lot less of the things that lived on them.

croes•40 minutes ago
"Them" refers to birds and small mammals and "even more" refers to the consequences of climate change where insects have more habitable areas.
aa-jv•44 minutes ago
Pets are slaves. Stop trying to own emotions.
Guthwine•16 minutes ago
Genuinely curious - are sheep kept for their wool also slaves in your opinion?
tonyedgecombe•18 minutes ago
Dogs have owners, cats have staff.
SJC_Hacker•40 minutes ago
More like cats enslaved humans
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rimworld•about 1 hour ago
lol