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The writer went to SF for a few days and went to one party where a group of friends were into peptides. From the article, they were also particularly terrible people. Just read this quote:
> “They change your personality, it’s literally made me less shallow knowing that we can just looksmax you.” “Ugliness is just a choice now.” “I shot up a twink with ozempic who did not need to lose any weight.”
I can’t believe I have to say this, but if someone is bragging to you about injecting weight loss drugs into another person who shouldn’t be taking weight loss drugs, your response shouldn’t be “lol how quirky”. You should recognize that they are a bad person. In my experience the drug enthusiasts who brag about getting other people started on their drugs are bad news, but the ones who brag about introducing to their drugs to people who clearly should not be taking those drugs are the worst variety.
These people always exist. Go back a few years and they might be talking about nootropics or “research chemical” drugs that are analogs of methamphetamine or MDMA. Go back further and they might be bragging about doing steroids and importing testosterone from gray market sources. Go back before that and they’d be bragging about all the Modafinil they’re taking.
The thing about drug user bubbles like this is that when you’re talking to them you’d be convinced that everyone is doing what they’re doing: Taking the latest on-trend drugs in large amounts and one-upping each other on dose, stories, or drug-fueled adventures.
What’s not talked about is the long-term consequences of falling into these groups where excessive drug self-experimentation is normalized. The party doesn’t last forever and the mindset of being able to endlessly adjust your body and/or your mood with drugs starts to turn dark after the early years where hubris makes users feel like they’ve found the secret to better living through chemistry.
If you’ve encountered groups like this you’ve also seen how the “everyone is doing it” mentality becomes embedded in their minds. That doesn’t mean everyone is importing various Chinese peptides and injecting them for “looksmaxxing” and whatever these people were on about about the “peptide party”. These are just garden variety young drug users riding the latest trend
EDIT: I replaced one instance of the word ‘journalism’ with ‘writing’ because it was becoming a pedantic distraction in the comments.
Lots of people from the 2010-ish era of "aesthetics" and steroids are having heart issues now in their 30s (or earlier). Pretty sad to see.
To me it's fairly clear where this comes from: ambitious people convinced they've figured out some secret cheat code that no-one else has. I'm yet to see that path end well for anyone.
> You should recognize that they are a bad person
Maybe I'm giving them too much credit but I don't really think they're bad people. Young, arrogant, stupid, unaware of the consequences of what they're doing sure... but I don't think it comes from a malicious place where they're intentionally trying to hurt others.
I think the author would agree with most of what you wrote.
You may enjoy Didion's 1967 Slouching towards Bethlehem[1], a similarly anecdotal (and substantially better-written) piece about the drug scene in SF's Summer of Love.
[1] https://www.saturdayeveningpost.com/2017/06/didion/
I think it’s important to understand that AI, even at its current level, is revolutionary as are cheap Chinese peptides. This isn’t a crypto bubble, both of these will be world changing. I’ve been doing AI for decades and peptides for 5 years (treating an actual medical condition) so I was in this space before it was cool, happy SF finally caught up.
Considering that "AI" before 2016 or so was, in terms of results, a whole different category, this may not be the flex you intend it to be. ;)
I turned to peptides because of how slow research has been, my medical condition (hEDS) has been known about since Hippocrates yet still no official treatments, so it’s not reasonable to expect one any time soon. Gray/black was my only option and will likely continue to be for the foreseeable future.
A lot of what we know about peptides comes from athletes cheating in sports and they’ve been doing it, some of them abusing it, for decades so the long term effects are not completely unknown. And this includes the GLP1As and the various combo stacks. Some people naturally have excesses of signaling peptides through genetic variation so they’re another good source of long term effects.
Of the things gay people inject into each other, ozempic is probably one of the safer options.
If someone’s writing in journalistic style I think it’s fair to criticize it as journalism, even if it’s on Substack
You are taking this far too seriously. It is a vignette which captures the flavor of a place at a particular time. And it is delightfully written.
There’s a motte and bailey thing going on with this type of rationalist writing where someone writes authoritatively on broad subjects and then when anyone starts responding to it they immediately repeats to “it’s just a blog” to forgive all of the problems with it.
certainly there is no organized journalistic outfit behind it, but also, a lot of legit journalists want their substacks to be taken as facts of record.
"Let me tell you about the weird people in my social circle I've chosen to write about ... aren't they weird? Now I'm going to draw massive conclusions about everyone in the Bay Area based on the extremely weird group (that I self-selected)."
The peptides and nootropics are the mildest things on the list, and yet here being compared to illegal stimulants and steroids? Those are not the same crowds at all.
Guess she's still your problem then.
Poor people.
However, this cuts both ways. This format is how we get some of the most interesting pieces of reporting about culture and counterculture. It's someone who went to some parties or worked for some companies. What you refer to as laziness is what makes it valuable: it recounts specific experiences instead of trying to speak in generalities. And it's descriptive rather than moralizing.
In the same vein, some of the most powerful exposes about neo-Nazi movements are just raw accounts of what's going on inside, without the author constantly repeating "and by the way, Nazism is bad, these people are all bad, and here are some statistics".
The SF Bay Area culture is probably not a thing, but there are some pretty awful subcultures within it, and many of them revolve around performance-enhancing drugs and rationalism-as-a-justification-for-bad-things (Zizians, longtermism, etc). I think we should own it.
But...
I'm also inclined to believe we are not the cool people being invited to these circles :)
Looking at what has happened with wegovy etc, it doesn't seem impossible.
Thats why I wrote that if you go back several years you’d find similar small social scenes around different trends: Steroids, Modafinil (when it was new and rare), RCs like 2-FA and MXE, or psychedelics depending on the era. Each time the social scenes that emerge around these have the same beliefs that everyone is doing excessive experimentation and that it’s only improving their lives. The later outcomes are not so rosy.
https://nymag.com/intelligencer/article/san-francisco-ai-boo...
I don't blame them - the collective optimism about AI has been replaced by paranoia.
So everyone is trying to make a fast buck before the music dies.
I work in big tech and have never heard anyone talk about "peptides". Is this a startup scene thing or just an SF thing? (I live in New York)
all of my coworkers are pretty normal, sure there are the stereotypical fitness types that are marathon training, cycling, or have a climbing gym membership but no one is talking about buying weird Chinese drugs
https://www.newyorker.com/magazine/2026/04/13/why-are-people...
Peptide manufacture is not as difficult as other drugs because they are injected.
Because the brand names cost a lot, and their manufacture is not too difficult, obviously lots of people got in on the action. Compounding pharmacies, gray market providers, and lots of cheap chinese copies. For one month cost of the name brand you could get many years worth of chinese copies. That is a pretty good hook.
Now that you are injecting one chinese peptide, and it works amazingly well, it is pretty common to check out some of the others. And it is hard to avoid since by the time you find the gray market / chinese suppliers, it is only one of the things they sell.
Like black market steroids except with less track record
I was close to a name brand pre-workout company and the FDA would play whack-a-mole with their formulas and they were on store shelves in every US city.
By analogy with “Bay Area House Party” stories, this piece intends to pick up on some of the wackiest new ideas in SV and extrapolate them to the point of ridiculousness. Go read Scott Alexander’s versions for context. One example is a conservative man moves to Oakland, observes that statistically most kids grow up transgender, decides to raise his daughter as a boy, so when they hit their teenage years they will “transition” gender into their birth gender. Another example is when the visitor to the Bay Area house party is talking to several people, each of which has an increasingly insane startup idea, always funded by Peter Thiel. Another is a house party organized by Claude Code, which everything is superficially sensible but totally insane LLM hallucinations when you look more closely.
> Claim: My uncle says Mamdani will abolish the entire NYPD.
> Fact: Your uncle does say that.
> Someone once said that SF is a town of extremely high sincerity, and all of its modern and historical weirdness — the AI doomerism, the cults, the hippies, the drug use, the polycules — is downstream of people saying things and other people taking them extremely seriously.
This is a perfectly reasonable usage - perhaps not the Hallmark greeting card one but it's certainly valid.
> the difference between the east coast and the west coast.
Having lived in and visited places on both sides of the US I can safely say that there is no single "difference" between them and that treating both as culturally monolithic (or their constituent places as broadly similar) is a massive category error. Boston is not Miami is not Atlanta just as San Francisco is not San Diego no matter how many people confuse them because they both start with "San".
People live so many parallel lives, even in a small town like San Francisco, that you can take so many paths through the scene without even going through the same points.
0: https://news.ycombinator.com/item?id=47672926
> Every single person that I met in SF was dangerously opinionated about AI best practices. It is impossible not to be! When everyone is constantly jumping from idea to idea, trying to stay on top of the Twitter firehose, you need some kind of opinion just to stay relevant and sane.
SF-specific assumptions aside, this the most useful takeaway. Seems they're calibration and signaling costs to being in the center of everything.
I read the whole thing. Good, easy writing style.
To my eye, the entire fascination of unsafely injecting peptides in a desire to change your being is largely the opposite of sincerity.
No, it's really a form of sincerity permitted by a sort of willfully affected naivete—adopted in pursuit of the strategy of Twain's amateur:
> The best swordsman in the world doesn’t need to fear the second best swordsman in the world; no, the person for him to be afraid of is some ignorant antagonist who has never had a sword in his hand before; he doesn’t do the thing he ought to do, and so the expert isn’t prepared for him; he does the thing he ought not to do: and often it catches the expert out and ends him on the spot.
— 1889, Mark Twain, “A Connecticut Yankee in King Arthur’s Court”
Hence why the "disruptors" so frequently, so irritatingly blast through Chesterton's Fence and/or market regulations.
Only one amateur in my portfolio need "catch" the incumbent "out".
Of course we can warp the semantics and argue that these people are "sincere" in their desire to defraud retail investors or something, but that doesn't seem to be the author's argument.
Fundamentally, the vast vast majority of founders who exit successfully made society better somehow.
But ... it's also true that founders who exit successfully are like 0.001% of the Bay Area's population, but we talk about them like they're 10% ... so we should all stop talking about them so much ;)
"Useful" is quite the euphemism.
> Fundamentally, the vast vast majority of founders who exit successfully made society better somehow.
This is an extraordinary claim.
I moved to the Bay Area in 1990 after graduation to work a corporate job in the valley but quit shortly after meeting a group of eccentrics that ran a small business setting up networks for commercial clients and joined their gig. I was making startup money before the word "startup" had any significant meaning. The skillset wasn't AI any kind of coding, but pure network admin. Companies paid obscene amounts of money for us to jumpstart their IT.
I moved into an 8 bedroom mcmansion (location omitted) with a rotating occupancy of about 10-20 people at any one time. We didn't do peptides, we did X and crystal, but it was near constant. The jargon was similar. And there were several houses like this from Oakland to Novato (to LA). It was just constant drugs, sex, partying and a little bit of work to cash a huge check. People moved through houses like they owned them, showing up and crashing, then going to another house, then flying down to LA and doing the same.
I burned out after 5 years of the lifestyle but kept in touch with the rolling scene that still had the same vibe through the startup madness of the late 90's (which unfortunately I missed out on due to years-long medical issues), but I've visited every few decades and it seems nothing has changed except we're greyer and fatter, and the houses are still monstrous, but cleaner and people wear clothing more often.
So when I hear stories like this, I'm glad to hear the culture hasn't changed and the torch has been passed.
Software is fun, but lots of people in other cities change the world without writing another AI harness. For example a group of aerospace engineers from across the country (Including Utah, Alabama, etc.) sent humans around the Moon and back. Something tells me they aren’t bragging about injecting research chemicals.
https://www.saturdayeveningpost.com/2017/06/didion/
It tries to be, but the person writing it isn’t an SF person. They said they visited SF and went to a party and now they’re lecturing us on SF social scenes from that experience.
Not directly related to the piece but this explains so much. I’ve always seen it as high credulity. That is to say all lots of people are lying but lots of other people trust them. The missing part has been why would you take some of these people at face value. If there’s also a lot of sincere people it would then make sense that many would end up overly credulous.
https://www.newyorker.com/magazine/2026/04/13/why-are-people...