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Discussion (58 Comments)Read Original on HackerNews
Caffeine affects the immune system via at least two opposing mechanisms.
Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor.
Mechanism 2: Raising intracellular cAMP (immunosuppressive) Caffeine also inhibits phosphodiesterase, the enzyme that hydrolyzes (i.e., breaks down) cAMP. cAMP accumulates inside immune cells, which acts as a "calm down" signal.
Note: both mechanisms are dose-dependent. At dietary caffeine levels, A2A antagonism likely dominates, whereas PDE inhibition is weak and mainly relevant at higher concentrations. However, the net immune effect in the tumor microenvironment remains unproven.
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If you would like to learn more, I can outline a framework for technical folks to ease in and become more informed on cancer. Gaps abound. The more people who understand cancer, the faster we get to cures. Moreover, personalized cancer treatment is the obvious future. Knowledge acquired now may pay off later (but hopefully not needed).
All you haters that give me grief for drinking my daily cup of decaf can shut up now.
Unfortunately it isn't without potential downsides.
That said, I do think there is some truth that decaf is lacking (including via supercritical CO2) and I wonder how long until we could have a product like genetically engineered coffee plants that produce everything except caffeine. I'd like that, though I can immediately see an issue with growing a plant without its natural pesticide.
https://youtu.be/yYTSdlOdkn0?si=uAo3pipjBA91OV5V
Coffee is not what defines your identity. It's fine to admit it isn't perfect.
Texas A&M also has a coffee research center dedicated to promoting and protecting global coffee trade and consumption so… yeah.
Do you have a source for this? Because it doesn't sound right to me. And also, I live in a coffee producing company, work adjacent to the coffee industry, and had a long conversation with someone planning to set up a business exporting green beans to the US, and their beans were getting tested to an extreme degree and being rejected for a few ppm over on certain things.
I have heard the 3% rule but fyi it's 1% in the EU and since there's actually not that many large scale decaffeination factories in the world, as far as I know they all target the EU level.
If you buy small batch, large batch, or somewhere in between it's probably been processed in one of these few large factories.
Not sure what the decaffeination process does, but it definitely does not preserve the taste of "untouched" beans.
It was ironic but interesting : dopamine is viewed as THE neurotransmitter of motivation while in fact it’s only one part of the mechanism. But it’s the part everyone is bragging about because it supports the idea that you can control your dopamine levels and be responsible of your own motivation.
The whole point of the argument was that your serotonin and noradrenaline levels were as much as important if not more, and, fat chance, you cannot buy serotonin or noradrenaline supplements. You have to be in mentally in a good place to get those right and that’s not something you have that much control over. Especially your noradrenaline levels are strongly tied to the quality of your environment and that’s why you should politically fight for a better life environment.
I didn’t dig in too deeply, but started drinking a morning cup of sugar free double mocha cappuccino, to help my workouts.
If I’m fooling myself, don’t tell me. I like the cappuccino.
We do, and that's called cancer;)