Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression

JKCalhoun•about 2 hours ago

I've always wondered if one dose of LSD could have been responsible for a fundamental change in my mind. There were other things of course going on in those college years, but I can say wth certainty that I became a very different person at some point in those early to mid twenties.

It's such that I have wondered if those I know who suffer various emotional issues might not benefit from a hallucinogenic trip—perhaps a rewiring of the mind.

tryagainian•41 minutes ago

Unfortunately life isn’t a triple-bling placebo controlled study.

There isn’t a cohort consisting entirely of otherwise identical yous we can use to retrospectively assess the outcomes of single-changes.

And besides, it’s not like one or any number of psychedelic experiences, results in a perfect human experience free of suffering or what have you.

pattilupone•31 minutes ago

I could use a triple-bling study...

tryagainian•12 minutes ago

Every Friday night after work, happy hour starts at 6.

crtified•about 1 hour ago

It may simply be that the intense disruption of a 5 hour long experience of chemically-induced novel pleasures - in people who'd long forgotten any form of enjoyment at all - while also being under special attention from caring professionals, is Very Nice Indeed. And that very nice experiences are the most direct salve that exists, when it comes to ameliorating a lifetime of unpleasant ones.

"I can say wth certainty that I became a very different person at some point in those early to mid twenties" - not to discount that, but I do suspect many developing adults (LSD or not) might make similar claims about distinct periods of mental change as they work their way into early adulthood.

larodi•8 minutes ago

There’s more evidence it is than it’s not. And, yes, even people who have been super stubbornly against psychedelics only very seldom come to regret taking some. Which you cannot say for other recreational or sedating stuff at all.

According to the GPTs, the LSD ranks the bottom in the chart of ‘damage done to your organism’ while alcohol tops it every time.

colechristensen•about 1 hour ago

> I can say wth certainty that I became a very different person at some point in those early to mid twenties

Let's be fair, most people do.

Efficacy and Safety of Psilocybin in Treatment-Resistant Major Depression

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