Paternal metformin use associated with major birth defects (2022)

Discussion (5 Comments)Read Original on HackerNews

j2j8•about 2 hours ago

That makes sense. Metformin is used as a testosterone lowering drug for feminizing masculine females with PCOS. If it's strong enough to help get rid of a beard on a very hairy woman, it's probably going to do something to a male even though they might otherwise have more testosterone to spare.

hxorr•about 2 hours ago

From my reading of various research etc, metformin has some marginal beneficial effect to blood sugar levels, but it is not clear cut as perhaps you might think. In comparison, what IS undeniably effective is making simple lifestyle changes like going for a walk after a meal, not eating right before bedtime, doing some simple resistance training etc. These have much more measurable effects than metformin, with none of the potential downsides.

JSR_FDED•about 2 hours ago

It’s on the World Health Organization list of essential medicines. 150M people rely on it to manage their diabetes. It’s been prescribed for 65 years.

Forgive me if I’m highly sceptical of your assertion that going for a walk after meals is an alternative to Metformin.

ralusek•27 minutes ago

In 65 years Ozempic will have been in use for 65+ years to help people lose weight, but that won’t make it untrue that going for a walk helps you lose weight.

OutOfHere•43 minutes ago

One needs to measure their HbA1c at home every few months to tell whether one still needs the prescription medicine. Seniors with low protein intake or low exercise will find that diabetes comes easily.

Obviously all processed carbs and red meat need to be cut out.

Vitamin B1 as thiamine is fairly important for glucose utilization. The benfotiamine form is additionally important.

There are just so many supplements for glucose regulation. I got my fasting glucose into the 80s by relying on psyllium husk and acacia fibers.

Ceylon cinnamon is good for post-meal glucose reduction.

Paternal metformin use associated with major birth defects (2022)

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Discussion (5 Comments)Read Original on HackerNews