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#more#successful#human#significant#mutations#brain#https#changes#ways#don

Discussion (42 Comments)Read Original on HackerNews

yubblegumabout 1 hour ago
> HAR1A is active in the developing human brain between the 7th and 18th gestational weeks.

Anyone know of a resource that layouts the temporal activation patterns for all the genes for the life cycle of a human being?

tgbugs33 minutes ago
Let's assume that you mean activation patterns at the level of single cells. Aside from the ethical issues which make it virtually impossible to obtain the full set of data, there is also the fact that the exact timing of expression is one of the major ways in which development produces variability in phenotype and so can vary wildly between individuals. The closest we have right now might be HUBMAP [0] or HCA [1], but I don't think that those had as objectives covering multiple developmental timepoints.

0. https://portal.hubmapconsortium.org/ 1. https://data.humancellatlas.org/

bonsai_spool42 minutes ago
This can't be done reliably but you may want to look at Tabula Sapiens which doe some of what you'd like. It's not an obvious problem in lots of ways.
yubblegum33 minutes ago
Thanks. Suprised no one has made a visualization (even if it has gaps).

> It's not an obvious problem in lots of ways.

Care to expand on this?

Link for others:

https://www.science.org/doi/10.1126/science.abl4896

https://maayanlab.cloud/Harmonizome/dataset/Tabula+Sapiens+G...

red75primeabout 7 hours ago
Interesting. So, the human brain is the scaled-up monkey brain with significant architectural changes.
timdiggermabout 1 hour ago
What did you think it was before you read this brief Wikipedia article?
graemep27 minutes ago
Of course it is, and you could say the same with regard to mammalian brains in general. However the divergence starts very early in development (seven weeks) so is very big and very significant. By the time a human is born the brain is very different from a monkey's.
tclancyabout 1 hour ago
Which is why we think we're the center of the universe.
utopiahabout 7 hours ago
What was the alternative?
lukeifyabout 2 hours ago
We didn’t have any. The project manager set it at 3 story points.
red75primeabout 6 hours ago
Scaling-up without significant architectural changes.
mapleoinabout 6 hours ago
Or significant architectural changes without scaling up.
curiousObjectabout 3 hours ago
Evolution would design the alternative to be something slightly less capable than the minimum. /s

Really, the likelihood is that these mutations must have had an impact that far outweighs their space in the genome.

That’s how all our close competition got murdered by Homo Sapiens. Just significant difference in mental abilities.

xatttabout 1 hour ago
There has to be a car analogy for this.
samrusabout 7 hours ago
Implies intelligent design

I think its rather some mutations that produced more reelin and created the most successful animal in earth's history

Joker_vDabout 4 hours ago
I'd really rather liked it if that supposedly "intelligent" designer took a bit more time at designing the urogenital tract of human males.
lexicalityabout 3 hours ago
I'd like it if the vagus nerve didn't do a loop around my neck for no particular reason. (Giraffes would probably like that even more)
codeulikeabout 3 hours ago
mine seems ok what version are you on
hackrmnabout 3 hours ago
Hey, $DEITY did its absolute best with the constraints and the requirements. But hey, can't please everyone apparently. Be happy you can relieve yourself well past the intended warranty period. The parts were designed to be easily _aftermarket_ replaceable with sufficient advances in technology, retaining the fundamental design without changes.
shmeeedabout 4 hours ago
What's wrong with it?
Miraltarabout 7 hours ago
The most successful animal by what metric?
menno-dot-aiabout 7 hours ago
Tetris high scores, obviously
totomzabout 5 hours ago
Some of us don't spend days looking for food, don't die of cold, and survive the flu...

aaand we have Quake and Comand&Conquer - Red Alert

Nevermarkabout 4 hours ago
The most successful at communicating their view that they are the most successful. Whether they are or not. But that means they are. By that metric.

Has another animal proposed they are more successful by a different metric?

Crickets?

incognito124about 2 hours ago
I fail to see that, it's simply one of all other random mutations, it's just that this one has a big downstream effect of enabling other more complex mutations
woadwarrior01about 4 hours ago
Merely implies a very good fitness function.
littlestymaarabout 4 hours ago
Yes. Though according this fitness function we're not necessarily more successful than a jellyfish or a tapeworm.
borborigmusabout 7 hours ago
So Steely Dan documented this first?
nurettinabout 2 hours ago
Intelligent mutations? How does that work?