Guy in his basement creates a drug to treat Alzheimer's disease using AI

ido•about 2 hours ago

Any subject matter experts care to chime in with your gut feeling about where this sits in the "promising potential treatment" to "AI psychosis" spectrum?

Avicebron•about 2 hours ago

It's closer right now to interesting hobby project from a guy who's trained in chemistry, like a guy who's a mechanic keeping a project car.

Maybe he publishes and it goes somewhere, I have a feeling getting approval for trials will be challenging with his setup as it is now.

I do like the "do chemistry the old fashion way" ethos though. I wish he added a blurb about why he's doing it this way

cucumber3732842•about 2 hours ago

>Maybe he publishes and it goes somewhere, I have a feeling getting approval for trials will be challenging with his setup as it is now.

Yeah, drug development is one of those things where practically the only way to make it to production is to let a big incumbent with a big enough war chest to drag it across the finish line buy it.

skeledrew•about 1 hour ago

If it isn't a potentially big money-maker said big incumbent won't touch it though. Will more likely try to shut it down especially if it overlaps with any of their more ludicrous offerings. And given the properties that this has (easy to manufacture, stable, soluble, low/no toxicity, etc) it's ripe for a shutdown because it'd make AD treatments far too cheap.

rtkwe•about 2 hours ago

"Potentially promising but likely to fail to replicate in human/non-mouse trials" is the easy default for new drug announcements, it's the modal outcome for drugs in this level of development, we've cured mouse cancers dozens of times over the years after all. The guy seems to have relevant expertise in the field so less likely to be purely AI driven nonsense.

amelius•about 2 hours ago

What does the guy's basement have to do with it? We live in the internet age, we can do anything anywhere. Was there not any other more relevant information to fluff up the headline? By the way, why are we still using twitter?

jorisw•about 2 hours ago

For those without Twitter accounts

https://xcancel.com/DouglasYaoDY/status/2070904914050797582

WarmWash•about 2 hours ago

Painfully editorialized headline.

He used AI to program robot arms.

throw310822•about 2 hours ago

"Meanwhile, LLMs (mainly ChatGPT Pro) were deeply integrated into virtually every step of the discovery process - I wouldn’t have been able to complete this project without them"

comboy•about 2 hours ago

Guy says he created a drug to treat Alzheimer's disease. Huge difference.

cristyansv•about 2 hours ago

> All of the in vitro screening was performed by an OpenTrons OT-2 liquid-handling robot programmed by Claude Code. Meanwhile, LLMs (mainly ChatGPT Pro) were deeply integrated into virtually every step of the discovery process - I wouldn’t have been able to complete this project without them

CPLX•about 2 hours ago

That does not seem to be an accurate description of what has happened here.

What it looks like is someone with significant biochemical experience and a Harvard PhD has created some kind of drug or chemical that he thinks will be effective for treating Alzheimer's, and that he mentions using Claude Code to help him program some of the complex chemical engineering machines that he used along the way.

microgpt•about 2 hours ago

Shush, you'll pop the bubble

mikelitoris•about 2 hours ago

How did LLMs not immediately shut down for “biosensitive” prompt or whatever bs they build into them nowadays?

binyu•about 2 hours ago

That behavior was only observed with the short lived Fable preview, Opus and other models do not seem to pose such limitation.

hhh•about 2 hours ago

They still have biology safeguards.

binyu•about 2 hours ago

Can you provide an example or a reproducible way to trigger it?

DonsDiscountGas•about 2 hours ago

Opus doesn't do that (at least it never has to me). I'm pretty sure codex doesn't either. It's just Fable

microgpt•about 2 hours ago

Because he only programmed robots to move A to B and didn't actually do any biology with AI

jqpabc123•about 2 hours ago

With help of AI, i developed a universal cure for all disease --- strychnine.

However, it does seem to have a few undesirable side effects.

Guy in his basement creates a drug to treat Alzheimer's disease using AI

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