Single Dose of Frog-Derived Gut Bacterium Eradicates 100% of Tumors in Mice

They used mice, because they are good for early tries. The researchers had 9 bacterias and only 1 was successful. Experiments in mice are cheaper and have less ethical problems than experiments in humans. (Hey! They even injected the cancer cells in mice and waited a week until it grow. Nobody will approve something like that in humans.)

The title claims that the tumos were eradicated. The title hides that it was a small tumor they injected in the mice and more importantly that it disappeared for two weeks until the experiment ended. It's difficult to guess if it will be useful for humans with bigger tumors because they are harder to detect, and it would work for a interesting enough period like 5 years.

There is also and old comment by octaane https://news.ycombinator.com/item?id=46308732 I'll quote it partially:

> Several things trigger my bullshit meter. Quote:

>> "This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"

> PD-L1 monoclonal antibodies are only effective against cancers that are PD-L1 positive. [...] Many tumor types are not PD-l1 positive.

> Doxy is an ancient SOC chemo.

> [...]

https://www.imdb.com/title/tt0104839/?ref_=fn_t_1

In it, Connery finds what looks to be a rare natural cure to all cancer in the Rain Forest (spoiler: not a frog, but equally as weird), and is literally battling the nearby deforesting and bulldozers. For a Sean Connery movie it was bizarre (As a young teen, I saw it in the theaters.. quite a bit less action than a 007 movie but good drama and dramatic Sean Connery acting).

Ewingella Americana itself is a quite common bacterial species, but it seems that the effective strain is the frog-derived and cultivated one. So don't go injecting yourself with a random E. Americana.

Full article: https://www.tandfonline.com/doi/full/10.1080/19490976.2025.2...

https://pmc.ncbi.nlm.nih.gov/articles/PMC12710904/

Also who thinks -- "hmm we've found a new random bacteria --- let's give a bunch of tumors to mice and then IV inject this random thing into them!"?

There must have been something about the microbe that gave them a hint. Maybe it's in the cited original article and was left out of the blog post.

Curing cancer in a mouse model is not at all uncommon in new therapies. Mouse models like this are vastly easier to treat than real world cancer for a bunch of reasons. Fully curing mice is the baseline for a treatment to even be considered for further evaluation. And even then very few therapies end up succeeding in humans - low single digit percent.

So yes, another possible treatment. But not at all a breakthrough.

https://asana.com/resources/eat-the-frog

They get all the good medical breakthroughs.

Is there any other source?

Seriously though, we are living in an era where the more the science broadens its horizons, the more it just looks like plain ol' witchcraft.

I'm hoping there'll be some uses for figs we haven't thought of, next ..