A Metallurgist's Doubts About Self-Replicating Probes

I studied material science in school specifically to try and address his concerns. Unfortunately they are all quite valid - the hard part isn't manufacturing, extruding, printing. Those are actually all quite reasonable (albeit not super space or weight efficient). The hard part is refining and ore enrichment, and most techniques that could possibly work in microgravity are almost impossible to test on earth. You would certainly need vitamins for electronics components for a time. Even much older computer chip architectures (1990s level) still require the clean room and 20-30 stages of prep. I believe an orbital chip fab is not only possible but, kind of ideal? Keeping it clean would be within reach - and it's mostly if not entirely an autonomous process from silicon monocrystal to assembled part today.

We're along way from self replicating probes. But I would argue were quite capable of autonomous mining, manufacturing and material transport - assuming we can figure out how to refine effectively. If someone wants a cool PhD project and ship an experiment to the ISS, I would argue an ionic or plasma based refining technique designed for micro gravity could be very interesting and very useful