AI in drug discovery — what it is, where we stand and the path forward

AAnodicElegy about 3 hours ago 26 commentsRead Article on nature.com

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Discussion (26 Comments)Read Original on HackerNews

tim333•19 minutes ago

Derek Lowe discusion of the paper https://www.science.org/content/blog-post/so-how-ai-drug-dis...

I think that was originally linked but got changed to the £30 to Elsevier version for some reason.

Xenoamorphous•about 2 hours ago

Need one for hair loss ASAP.

newsomix9xl•about 2 hours ago

Indeed. My plans for a youthful Mohawk are being stymied by the lack of AI promised medical breakthroughs.

Wheres my follicles dammit?

xX_Hacker_Xx•about 1 hour ago

there is a AI designed drug for hair loss that i know of.

its slow-release oral minoxidil formulation called MINX. AI helped with the formulation [1].

its in in similar category as VDPHL01. Hundreds of millions if not a billion dollars has been invested into Veradermics, and their main product is VDPHL01 (also an extended-release oral formulation).

[1] https://x.com/anagenxyz/status/2071601868841595082

kridsdale1•27 minutes ago

I’m on 0.5 to 1mg oral minoxidil daily for a few years now and it’s working great. Blood pressure benefits too.

asxndu•about 2 hours ago

Already exists (finasteride), only problem is that it castrates you chemicallym

gradus_ad•about 2 hours ago

For everyone struggling with hair loss but concerned about side effects of Fin. Look into topical fin. It produces higher concentrations of the medication in the scalp and lower systemic concentration. Not perfect, but better.

skepticATX•about 2 hours ago

About 2% of finasteride users experience these side effects, and they are reversible after discontinuation.

pton_xd•about 2 hours ago

Apparently some users report persistent side effects even years after stopping the medication (post-finasteride syndrome).

pstuart•about 2 hours ago

Yep. Not everybody but enough to warrant vigilant monitoring and titration.

alpineidyll3•about 2 hours ago

Absci has a good asset coming out pretty soon that you could try to get on the trial.

p-o•about 2 hours ago

We're all about to come face to face with this reality. This dance can only last so long.

GolfPopper•about 2 hours ago

>We're all about to come face to face with this reality. This dance can only last so long.

Only for values of 'all' that exclude well-connected members of the billionaire class and their select associates.

alpineidyll3•about 2 hours ago

if you think the state of the art in this area is something you'll hear about from a guy that looks like santa in an academic journal, your investments deserve what's about to happen to them.

Oarch•about 1 hour ago

[AI drug discovery] was never the hard part.

cryptographical•about 1 hour ago

need one for brain plasicity. it would be nice to be able to easily learn a foreign language or musical instrument naturally.

bothers•3 minutes ago

Easily? Have you ever actually learned a second language or an instrument as a child?

KellyCriterion•about 1 hour ago

There is one!

Ketamin should have huge impacts on neuro/brain plasticity when used properly (i.e. in therapy)

immmmmm•about 1 hour ago

Psychedelics are several orders of magnitude stronger on the plasticity front.

In therapy as well.

consensus1•20 minutes ago

Psilocybin has this effect. Source: I can't remember where I read it, so low confidence.

WarOnPrivacy•about 2 hours ago

nerd-fanboi proposal: Articles by national treasures (like Derek Lowe, Raymond Chen) should be highlighted with specific identifiers on HN - like a distinctive title font or an ascii diamond ◊.

snapetom•about 2 hours ago

No thanks. Social media needs less hero worship. Just RSS whoever you like.

chrisjj•about 1 hour ago

Has this yet produced a treatment for AI psychosis?

No? Well fancy that! :)

EA-3167•about 2 hours ago

> "The paper goes on to make recommendations for AI companies and investigators, and these are well worth reading. The common theme is that people need to think more about why they’re doing certain techniques or using certain technologies, rather than just using them because they’re newly available."

Please. Please let some people with power and influence understand this lesson sooner rather than later. I understand the reasons that's unlikely to occur, but usually the impact isn't quite so drastic and expensive as this is. Just because something is new and shiny doesn't mean that it'll produce the outcomes you need at the other end, and until it's shown that capability your approach to it should be MODERATE.

bbondo•about 2 hours ago

Drug discovery scientists think about what they're doing and why ALL THE TIME. AI stuff is just another tool.

It's also worth mentioning that drug development timelines typically exceed the interval in which these technologies have been available (or at least effective). Measuring impact will take a long time.