AlphaGenome Atlas predictive map of every DNA letter change in the human genome

Discussion (8 Comments)Read Original on HackerNews

BigTTYGothGF•about 3 hours ago

Meanwhile someone went and did the experiment on the equivalent problem in a virus: https://www.science.org/content/blog-post/mutate-em-all-and-...

adrian_b•about 1 hour ago

And various dedicated AI models all made poor predictions of the results of that experiment, which casts doubts about the value of the AlphaGenome predictive map.

A virus is much simpler than a human, but even for that simple virus the effects of most of the mutations could not be predicted. A half of the mutations had harmful effects, and for a half of those it is unknown for now why they were harmful.

For a human the uncertainty about the effects of a mutation will be far greater than for one of the simplest viruses.

jenders•42 minutes ago

If you like that abstract geometric headline image, you might also like the source artist their model “learned” it from: https://leegriggs.com/xgen-rendered-with-arnold-for-maya

hn1rig3rak•about 2 hours ago

the catch with a genome-wide map is the benchmark labels came from conservation, so you can't tell prediction from re-reading the prior.

bonsai_spool•about 1 hour ago

> benchmark labels came from conservation

And from human disease...?

thelaxiankey•about 1 hour ago

this is literally not possible. while I'm excited for these kinds of things, alphafold is already imperfect, and this basically side-steps actual structural predictions. it sounds good, but frankly biology is not there yet. in practice not even alpha fold can tell me if my gfp fusion will work...

tejtm•2 minutes ago

gfp --- green fluorescent protein

glow in the dark jelly fish bits that biologist stick in other critters to see if, when and where it shows up (under a blacklight).

ChrisArchitect•about 2 hours ago

Some more discussion: https://news.ycombinator.com/item?id=49611251

AlphaGenome Atlas predictive map of every DNA letter change in the human genome

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Discussion (8 Comments)Read Original on HackerNews